Celosome® HA-Lidocaine Implant
Advanced hyaluronic acid dermal filler with 24mg/ml cross-linked HA + 0.3% lidocaine, featuring <2ppm BDDE residues and 98.7% purity index (USP 34 testing standard)
Advanced Cross-linking Technology & Medical Compliance
Celosome utilizes patented SMART Cross-linking™ technology (US Patent No. 10,987,445) manufactured under ISO 13485 certified facilities. The 8-stage purification process includes 0.1μm membrane filtration and endotoxin removal columns, achieving <0.05 EU/ml pyrogen levels. Rheological testing demonstrates G’ value of 350 Pa and viscosity of 82 Pa·s at 2.5Hz frequency, optimized for deep tissue implantation.
Clinical Advantages
Optimal Rheology
G’ 350 Pa elasticity for structural support with 82 Pa·s viscosity for smooth tissue integration
Safety Profile
0.02% adverse event rate in 12-month follow-up (n=1,542 patients)
Duration
Median persistence 18 months (range 12-24mo) in mid-face volumization
Technical Specifications
- Composition: 24mg/ml HA, 0.3% lidocaine HCl
- BDDE Residue: ≤2ppm (HPLC-UV)
- Needles: 27G×1/2″ ×2 included
- Volume: 1.1ml sterile syringe
- Storage: 2-25°C protected from light
Clinical Protocol
- Depth: Subcutaneous/Supraperiosteal
- Technique: Retrograde linear threading
- Max Dose: 2.2ml per session
- Anesthesia: Integrated lidocaine
- Follow-up: 2-week assessment required
Recommended Applications
Mid-face Volumization
For malar enhancement: Deposit 0.05-0.1ml aliquots in supraperiosteal plane using 27G needle. Maximum 1.5ml per mid-face quadrant.
Mandibular Contouring
Pre-jowl sulcus injection: Administer 0.3-0.5ml per side subcutaneously. Use 30° insertion angle for optimal product placement.
Medical Notice
Important: Results may vary ±15% based on individual tissue characteristics and injection technique. Must be administered by licensed practitioners with dermal filler certification. Contraindicated in patients with active skin infections or hypersensitivity to lidocaine.
Post-treatment monitoring for vascular complications required. Not intended for lip augmentation or superficial dermal injection. Report adverse events to local health authority and manufacturer.
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